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HomeCISNE Score (Febrile Neutropenia)
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CISNE Score (Febrile Neutropenia)

Clinical Context & Background

The CISNE score predicts the risk of serious complications in patients with solid tumors and apparently stable febrile neutropenia (FN). It complements the MASCC index by specifically stratifying risk within the "stable" subgroup, helping identify those truly safe for outpatient care.
Primary Source EvidenceCarmona-Bayonas A, Jiménez-Fonseca P, Virizuela Echaburu J, et al. Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia (CISNE). J Clin Oncol. 2015;33(5):465-471.
Formula Logic
Sum of points for ECOG, COPD, CV disease, Mucositis, Monocytes, and Hyperglycemia.

Reference Data

Risk ClassScoreComplication Rate
Low Risk01.1%
Intermediate1 - 26.2%
High Risk≥ 336%

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