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NIH GIST Risk (Miettinen)
Clinical Context & Background
The NIH (Fletcher) Consensus Criteria stratifies the risk of aggressive behavior and metastasis in Gastrointestinal Stromal Tumors (GIST) based on tumor size and mitotic index. Note: It does not account for tumor location (see AFIP-Miettinen criteria for location-specific risk).
Formula Logic
Risk matrix based on Size (cm) and Mitoses (/50 HPF).Reference Data
| Risk Group | Tumor Size | Mitotic Count (/50 HPF) |
|---|---|---|
| Very Low Risk | < 2 cm | < 5 |
| Low Risk | 2 - 5 cm | < 5 |
| Intermediate Risk | < 5 cm | 6 - 10 |
| Intermediate Risk | 5 - 10 cm | < 5 |
| High Risk | > 5 cm | > 5 |
| High Risk | > 10 cm | Any count |
| High Risk | Any size | > 10 |
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