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HomeCUPI Score (Cancer of Unknown Primary)
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CUPI Score (Cancer of Unknown Primary)

Clinical Context & Background

The Cancer of Unknown Primary Index (CUPI) stratifies patients with metastatic carcinoma of unknown primary (CUP) into two prognostic groups. It is based on performance status, histology, and specific metastatic sites/lab values. Low-risk patients have significantly better survival and may benefit from more intensive therapy.
Primary Source EvidenceFizazi K, Culine S, Schnitzler A, et al. Carcinoma of unknown primary site: data on 1000 consecutive patients. J Clin Oncol. 2003;21(9):1725-1731.
Formula Logic
Sum of weighted prognostic factors (Performance Status, Histology, Liver/Bone Mets, ALP, LDH, Albumin).

Reference Data

Risk GroupTotal ScoreMedian Survival (Historical)
Low Risk< 27 (approx)11+ months
High Risk≥ 274 months

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