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CNLC Staging (China)

Clinical Context & Background

The CNLC staging system (Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China) generally recommends more aggressive interventions than BCLC for intermediate and advanced stages, reflecting differences in etiology (HBV) and surgical practice in China.
Primary Source EvidenceXie DY, Ren ZG, Zhou J, Fan J, Gao Q. 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights. Hepatobiliary Surg Nutr. 2020;9(4):452-463.
Formula Logic
Classification based on PS, Liver Function, and Tumor extent.

Reference Data

CNLC StageDescriptionTreatment
IaSingle < 5cmResection / Ablation
IbSingle > 5cm or 2-3 nodules < 3cmResection / Ablation / TACE
IIa2-3 nodules > 3cmTACE / Resection
IIb≥ 4 nodulesTACE / Systemic
IIIaVascular InvasionTACE / Systemic / Radiotherapy
IIIbExtrahepatic MetsSystemic Therapy
IVTerminalSupportive Care

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