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HomeStage II Colon Cancer Risk Assessment
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Stage II Colon Cancer Risk Assessment

Clinical Context & Background

NCCN and ASCO guidelines recommend assessing high-risk features in patients with Stage II Colon Cancer (T3N0/T4N0) to decide on adjuvant chemotherapy. Patients with high-risk features may benefit from chemotherapy (e.g., CAPOX/FOLFOX or 5-FU), while low-risk patients may be observed.
Primary Source EvidenceBenson AB, Schrag D, Somerfield MR, et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol. 2004;22(16):3408-3419. (Updated in subsequent NCCN guidelines).
Formula Logic
Presence of any high-risk factor increases recurrence risk.

Reference Data

Risk GroupRecommendation
Low Risk (No factors)Observation or Fluoropyrimidine mono-therapy
High Risk (Any factor)Consider Adjuvant Chemotherapy (Doublet or Mono)

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