HCT-CI (Transplant Risk)

Pulmonary: Moderate/Severe (DLCO/FEV1 < 80% or Dyspnea)?

Arrhythmia (Afib/Flutter, Sick Sinus, Ventricular)?

Cardiac (Coronary Artery Disease, MI, EF ≤ 50%)?

Heart Valve Disease (except mitral valve prolapse)?

Inflammatory Bowel Disease (Crohn's/UC)?

Diabetes / Endocrine?

Cerebrovascular Disease (TIA/Stroke)?

Psychiatric Disturbance (Depression/Anxiety requiring tx)?

Hepatic (Mild: Bili > ULN to 1.5x / AST/ALT > ULN to 2.5x)?

Obesity (BMI > 35 kg/m²)?

Infection (requiring continuation of tx after day 0)?

Rheumatologic (SLE, RA, etc)?

Peptic Ulcer (requiring tx)?

Renal (Creatinine > 2 mg/dL or Dialysis)?

Prior Solid Tumor?

Clinical Context & Background

The HCT-CI (Sorror Score) predicts non-relapse mortality (NRM) and survival after allogeneic hematopoietic cell transplantation. It sums weighted comorbidities to stratify transplant risk.

Primary Source EvidenceSorror ML, Maris MB, Storb R, et al. Hematopoietic cell transplantation-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106(8):2912-2919.

Formula Logic

Sum of weighted comorbidities (1-3 points each).

Reference Data

Score	Risk Group	2-Year NRM Estimate
0	Low Risk	14%
1 - 2	Intermediate Risk	21%
≥ 3	High Risk	41%

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HCT-CI (Transplant Risk)

Clinical Context & Background

Reference Data

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