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HLH-2004 Diagnostic Criteria
Clinical Context & Background
The HLH-2004 guidelines establish the clinical diagnosis of Hemophagocytic Lymphohistiocytosis (HLH). A molecular diagnosis is consistent with HLH. In the absence of a known genetic mutation, a diagnosis can be made if at least 5 of the 8 clinical and laboratory criteria are met.
Formula Logic
Diagnosis requires ≥ 5 of 8 criteria.Reference Data
| Criteria Met | Interpretation |
|---|---|
| 0 - 4 | Not Diagnostic (unless genetic proof exists) |
| 5 - 8 | Diagnostic for HLH |
Evidence-based oncology decision support. Verify with clinical guidelines.