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IPSET Thrombosis Score

The International Prognostic Score for Essential Thrombocythemia (IPSET) predicts thrombosis risk in essential thrombocythemia patients to guide antiplatelet or cytoreductive therapy decisions.

Purpose:
Stratify thrombosis risk in essential thrombocythemia (low, intermediate, or high risk)
Population:
Patients diagnosed with essential thrombocythemia (ET)
Factors:
Age >60 years, Cardiovascular risk factors, JAK2 V617F mutation, Prior thrombosis
Reference:
Barbui et al., Blood 2012
HomeIPSET-Thrombosis (Essential Thrombocythemia)
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IPSET-Thrombosis (Essential Thrombocythemia)

Clinical Context & Background

The International Prognostic Score for Thrombosis in Essential Thrombocythemia (IPSET-Thrombosis) stratifies ET patients into risk groups to guide aspirin and cytoreductive therapy (e.g. Hydroxyurea).
Primary Source EvidenceBarbui T, Finazzi G, Carobbio A, et al. Practice-relevant revision of IPSET-thrombosis based on 1019 patients with WHO-defined essential thrombocythemia. Leukemia. 2015;29(12):2411-2415.
Formula Logic
Points: Age > 60 (1), History of Thrombosis (2), JAK2 V617F (2), CV Risk Factors (1).

Reference Data

Risk GroupTotal ScoreThrombosis Risk (%/yr)
Very Low01.03%
Low12.35%
Intermediate22.86%
High≥ 33.56%

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