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ProMark® Proteomic Score
Clinical Context & Background
ProMark is an automated immunofluorescent assay that measures the levels of 8 signaling proteins in FFPE prostate tumor tissue. The resulting score (0 to 1) predicts the probability of finding adverse pathology (Gleason ≥4+3 or non-organ confined disease) at radical prostatectomy.
Formula Logic
Score 0.0 to 1.0 based on 8-protein signature.Reference Data
| ProMark Score | Risk Level | Recommendation |
|---|---|---|
| < 0.33 | Low Risk | Supports Active Surveillance |
| 0.33 - 0.80 | Intermediate Risk | Individualized decision |
| > 0.80 | High Risk | Consider Definitive Treatment |
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