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HomeAFIP GIST Risk (Miettinen)
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AFIP GIST Risk (Miettinen)

Clinical Context & Background

The AFIP (Miettinen) criteria improve upon the NIH criteria by incorporating tumor location (Stomach, Duodenum, Jejunum/Ileum, Rectum), recognizing that gastric GISTs generally have a better prognosis than intestinal GISTs of similar size/grade.
Primary Source EvidenceMiettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23(2):70-83.
Formula Logic
Risk of progression % based on Size, Mitoses, and Site.

Reference Data

Risk GroupRisk of Progression
None0%
Very Low1 - 10%
Moderate10 - 30%
High> 30%

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