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GPA (Graded Prognostic Assessment)
Clinical Context & Background
The Graded Prognostic Assessment (GPA) is a prognostic index for patients with brain metastases. It is considered more accurate than the RPA as it is quantitative. Scores range from 0 (Poor) to 4 (Best). Note: This is the original GPA; specific DS-GPA (Diagnosis-Specific) nomograms exist for different primary sites.
Formula Logic
Sum of scores (0, 0.5, 1.0) for Age, KPS, # of CNS Mets, and Extracranial Mets.Reference Data
| GPA Score | Median Survival |
|---|---|
| 0 - 1.0 | 2.6 months |
| 1.5 - 2.5 | 3.8 months |
| 3.0 | 6.9 months |
| 3.5 - 4.0 | 11.0 months |
Evidence-based oncology decision support. Verify with clinical guidelines.