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Residual Cancer Burden (RCB)
mm
mm
%
mm
Clinical Context & Background
The Residual Cancer Burden (RCB) score quantifies the extent of residual disease in the breast and axillary lymph nodes after neoadjuvant chemotherapy. It is a continuous variable that correlates strongly with distant relapse-free survival.
Formula Logic
RCB = 1.4(finv × dprim)^0.17 + [4(1 - 0.75^LN) × dmet]^0.17Reference Data
| RCB Class | Score Range | Prognosis |
|---|---|---|
| RCB-0 | 0 | Pathologic Complete Response (pCR) |
| RCB-I | 0 - 1.36 | Minimal Burden (Good Prognosis) |
| RCB-II | 1.36 - 3.28 | Moderate Burden |
| RCB-III | > 3.28 | Extensive Burden (Poor Prognosis) |
Evidence-based oncology decision support. Verify with clinical guidelines.