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UISS (UCLA Integrated Staging)
Clinical Context & Background
The UCLA Integrated Staging System (UISS) stratifies patients with localized (non-metastatic) renal cell carcinoma into three risk groups based on TNM Stage, Fuhrman Grade, and ECOG Performance Status. It predicts overall survival after nephrectomy.
Formula Logic
Risk group based on T-stage, Grade, and ECOG.Reference Data
| Risk Group | Criteria | 5-Year Survival |
|---|---|---|
| Low Risk | T1-T2 N0 M0, Grade 1-2, ECOG 0 | 91% |
| Intermediate Risk | All other combinations | 80% |
| High Risk | T3 N0 M0 or Grade 3-4 or ECOG ≥ 1 | 55% |
Evidence-based oncology decision support. Verify with clinical guidelines.